Eye discomfort can be a symptom of various eye diseases, including glaucoma.

The frequent movement of 3D game visuals can trigger dizziness and nausea, as the human balance sensory organs receive inconsistent movement signals, leading to the brain producing contradictory and uncomfortable responses, thereby issuing dizziness commands to slow down or stop the movement in the game. This situation usually occurs when playing 3D games for extended periods without a break, and it varies from person to person; some may be particularly sensitive.