Newborn hemolytic disease refers to incompatibility between the mother and baby’s blood types, where the mother’s blood contains immune antibodies IgG against the fetus’s red blood cells, which pass through the placenta into the fetal circulation, causing a cross-reactive immune response that leads to the destruction of fetal and newborn red blood cells and resulting in hemolysis. Pre-natal treatment can include plasma exchange in pregnant women, intrauterine transfusion, and consideration of early delivery; post-natal treatment includes blood transfusion therapy, phototherapy, correcting anemia, and symptomatic treatment. Additionally, active treatment and management for jaundice are necessary to prevent complications.