Most neonates with intracranial infections can be completely cured with active and effective treatment, leaving no sequelae and no recurrence. However, severe intracranial infections that also involve infections or damage to other organs of the entire body and mind may result in neurological damage, which could lead to sequelae. Neonates diagnosed with sepsis should be hospitalized for thorough anti-infection treatment to timely and effectively stop the progression of the disease. It is also very important for parents to pay attention to preventing neonatal sepsis. In everyday life, they should always ensure proper care of their baby’s skin and mucous membranes to reduce the risk of infection.