Hand, Foot, and Mouth Disease patients often experience high fever, with temperatures ranging from 38℃ to 40℃, lasting for 4 to 7 days. In the early stages of the illness, some children may have symptoms such as runny nose, sore throat, loss of appetite, dry heaves, and nausea or vomiting. Not long after the onset of the disease, red small papules will appear on the child’s fingers, toes, and mouth, quickly transforming into small blisters. These blisters are about 2-4 millimeters in diameter, resembling grains of rice, and are circular or oval in shape with a red halo around them. This type of rash can also appear on the child’s buttocks and around the anus. Clinically, the characteristic of the disease is the appearance of blisters on the hands, feet, and mouth.