A boy, six years old, had been vaccinated with the hepatitis B vaccine as per the schedule three times. However, during tests in May and September this year, it was found that he had not produced antibodies. The lack of antibody response to the hepatitis B vaccine is related to the vaccine’s effectiveness and the body’s immune system, and can be re-vaccinated. It is recommended to try a different manufacturer’s hepatitis B vaccine or use a 60 microgram high-dose vaccine, and check the antibody levels one month later. It is advisable to take the child for vaccination as soon as possible, while also being cautious to avoid sharing utensils and other items with others.