Neonatal hemolytic disease is caused by incompatibility between the baby’s and the mother’s blood types. In severe cases, it may lead to symptoms such as jaundice, anemia, restricted motor skills in hands and feet, and even heart failure, respiratory distress, and edema. It is crucial to provide scientific feeding, a balanced diet, and active treatment to prevent the worsening of the condition. Among these children with compatible blood types, 20% suffer from hemolytic diseases. Rh-negative Rh blood type is quite high, most often seen in the second child, and this hemolytic disease is relatively more dangerous.