Down syndrome, also known as mongolism and trisomy 21, is one of the most common chromosomal diseases causing intellectual disability. Its main characteristics include intellectual disability, growth delay, distinctive facial features, palm perforations, congenital heart disease, and gastrointestinal malformations. The prevalence of Down syndrome is not directly related to race or living standards, with an estimated one in every 660 newborns affected, making it the most common chromosomal abnormality.