Distinguishing Hand, Foot, and Mouth Disease from Chickenpox

The difference between hand, foot, and mouth disease and chickenpox lies in the distribution, size, color, and itching of the rash. The rash of hand, foot, and mouth disease is mainly distributed on the hands, feet, and mouth, smaller in size and not itchy; chickenpox blisters are systemic, larger in size with thin skin, and itchy.
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Distinguishing Hand, Foot, and Mouth Disease from Herpangina

The difference between hand, foot, and mouth disease and herpangina lies in the former causing red rashes on the hands, feet, and buttocks, and being highly contagious; while the latter primarily affects the throat, with milder symptoms and lower contagiousness. Both can be treated with antiviral medications, and in severe cases, may require medical treatment involving intravenous or intramuscular injections. In addition, maintaining good personal hygiene habits and a balanced diet can also help prevent and treat these conditions.
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Distinguishing Hand, Foot, and Mouth Disease from Pediatric Exanthema

Hand, foot, and mouth disease and pediatric exanthema are both acute infectious diseases caused by viral infections, primarily transmitted through droplets and contact. Although the symptoms are similar, there are differences. Hand, foot, and mouth disease primarily presents with blisters on the palms, soles, and mucous membranes of the mouth, while pediatric exanthema is characterized by fever and rash.
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