Question
A 28-year-old pregnant woman inquired about her Down syndrome screening at 11 weeks and 2 days, with a PAPP-A index of 623.14 mU/L and an adjusted MoM value of 0.30, both below the normal range (0.43). She asked whether her condition was severe, if there was a possibility to increase the index, and if there was a risk of genetic disease.
Answer
A medical professional responded that a single screening result cannot fully assess the health risks of the fetus. Based on the results of the PAPP-A, F-βHCG, and screenings for trisomy 21 and trisomy 18, the woman’s current risk remains low. It is recommended to undergo a detailed ultrasound examination around 20 weeks to confirm whether the fetus has any abnormalities. Additionally, medical professionals will further understand the woman’s family history of genetic diseases, personal health status, and past pregnancy history.