Inquiry
What is the most important test in Down syndrome screening, and what if the result is not good?
Answer
The Down syndrome screening primarily measures the concentrations of alpha-fetoprotein, human chrionic gonadotropin (HCG) hormone, and free estriol in the maternal serum, and combines this with data such as due date, weight, age, height, and gestational age to calculate the risk coefficient for giving birth to a fetus with congenital defects. Regarding the severity of the results, if the screening indicates a high risk, further tests such as amniocentesis or non-invasive prenatal testing may be necessary to confirm the fetus’s health status. A confirmed diagnosis of Down syndrome or other congenital defects can impose a significant emotional and financial burden on the family.