Question
After screening by the Disease Control Center, the newborn’s propionylcarnitine (C3) index has risen. Is it necessary to undergo further tests to rule out methylmalonic acidemia?
Answer
If the propionylcarnitine (C3) index is only slightly elevated and no related symptoms are present, it may be considered to undergo another test for confirmation. If diagnosed with methylmalonic acidemia, a specific dietary therapy may be required.