Pediatrics: Will Parents with AB and O Blood Types Give Birth to a Baby with Hemolytic Disease?

Question

Will a child born to an AB-negative mother and an O-negative father develop hemolytic disease?

Answer

Children born to an AB-negative mother and an O-negative father usually do not suffer from hemolytic disease. It is only when the mother is O-negative that the risk of hemolytic disease arises, which is similar to the principle of blood transfusion where AB-negative blood can accept O-negative blood.