Question

What are the pathological classifications and diagnostic criteria for nephrotic crescentic glomerulonephritis?

Answer

Nephrotic crescentic glomerulonephritis is an immune-mediated glomerular disease, and its pathological classification mainly includes the following:

  1. International Society of Paediatric Nephrology (ISPN) Pathological Classification:
    • I: Minimal change
    • II: Mesangial proliferation
    • III:
      • (a) Focal
      • (b) Diffuse proliferation or sclerosis, crescent formation in 75%
    • VI: Membranous proliferative lesion
  2. World Health Organization (WHO) Pathological Grading:
    • I: Including minimal change, minimal change with focal segmental prominent
    • II: Including mild diffuse proliferative glomerulonephritis, mild diffuse proliferative glomerulonephritis with focal segmental prominent
    • III: Including moderate focal proliferative glomerulonephritis, moderate diffuse proliferative glomerulonephritis
    • IV: Including severe diffuse proliferative glomerulonephritis, end-stage kidney In the treatment of nephrotic crescentic glomerulonephritis, both traditional Chinese and Western medicine have their advantages. Western medicine treatment often uses hormones and other medications, but the effect is limited, and side effects may occur.