Question
A 5-year-old girl was born with curved legs and delayed intellectual development. A chromosome test revealed a long arm deletion on the 18th pair of chromosomes. The parents want to know if such a chromosome deletion is suitable for neural stem cell surgery, as well as the feasibility and expected outcomes of the procedure.
Answer
Hypoxic-ischemic encephalopathy (HIE) is a multi-step and multifactorial pathophysiological process, with varying tolerance to hypoxia among different individuals. Therefore, the treatment of HIE should be personalized and comprehensive at each stage of hypoxia-ischemia, to enhance treatment efficacy and reduce side effects. Cerebral palsy (CP) is a syndrome caused by non-progressive brain injury during the prenatal to postnatal period of brain development, characterized primarily by central motor disorders and postural abnormalities. There are certain differences between the 18th pair chromosome long arm deletion and cerebral palsy.