Question
Will hemolysis occur if both the child and mother are O-type blood?
Answer
ABO incompatibility hemolytic disease can occur when the mother has O-type blood and the father has A-type, B-type, or AB-type blood. However, not all babies will develop the disease, and the severity of symptoms can vary, depending on the mother’s antibody levels, the extent of antibody binding to fetal red blood cells, the strength of A or B antigens, and the fetal compensatory hematopoietic ability.