Question
What are the effects of chromosomal balanced translocations?
Answer
The inheritance of chromosomal diseases can impact the fertility and health of the next generation. If physical deformities occur, it is recommended to undergo a comprehensive examination before pregnancy. For patients with chromosomal balanced translocations, although natural conception is possible, it is prone to lead to embryo death or miscarriage, and even may cause fetal malformations. The chances of passing it on to males and females are the same. Prenatal diagnosis during pregnancy can be chosen to exclude the possibility of fetal malformations. If the results are normal, the pregnancy can continue. Alternatively, third-generation IVF technology can be used to screen for normal embryos for transplantation. If chromosomal balanced translocation occurs in males, a check of seminal fluid for normality is required. If the seminal fluid quality is poor, third-generation IVF technology may be needed to assist in conception.