Question
The patient is 11 years old and has noticed breast tenderness and hard lumps upon palpation half a month ago. After a hospital examination, it was revealed that the child’s development is more than a year ahead of their peers, with doctors suggesting increased physical activity and reducing the consumption of hormone-containing foods, such as fried foods and KFC.
Answer
The patient may be facing simple breast precocity, which is a form of partial central precocious puberty. After GnRH stimulation, FSH levels rise significantly but LH levels do not increase obvious, with FSH/LH>1. However, PICPP may transform into true CPP without clinical symptoms. Therefore, regular follow-up is required after a diagnosis of PICPP, especially for cases where breast enlargement recurs or persists without regression, and repeat stimulation tests may be necessary. Additionally, attention should be paid to special cases such as CPP resulting from non-central precocious puberty and precocious puberty associated with congenital hypothyroidism.