Question
How long does mifepristone remain in the body before it is completely decomposed and metabolized?
Answer
After oral administration, mifepristone is rapidly absorbed by the digestive system. The peak concentrations of the metabolite and the unchanged mifepristone in the blood are reached at 1.5 and 0.81 hours, respectively, at levels of 0.8mg/L and 2.34mg/L. However, there are significant differences between individuals. The complete elimination of the drug from the body is relatively slow, with an elimination half-life of approximately 20 to 34 hours. After 72 hours of taking the medication, the drug concentration in the blood can still be maintained at about 0.2mg/L. Mifepristone has a significant first-pass effect, with the concentration of the metabolites in the blood being lower than that of the parent compound within 1 to 2 hours after oral administration.