Question

When should penicillin skin test solution be prepared?

Answer

Penicillin skin test solution should only be prepared when needed. Past treatment records and outcomes indicate that the concentration of penicillin acid in a penicillin solution stored at 37℃ for 24 hours can increase by approximately 200 times. Additionally, the pH value of the solution decreases over time, temperature, and concentration, which promotes the aggregation of penicillin to form large molecular allergenic polymers. Using such a solution for the skin test may lead to false-positive reactions or anaphylactic shock. Therefore, prepared skin test solutions should be stored in a low-temperature environment and used only on the same day.