Question
The dosage for the cefotiam skin test in our hospital is 0.1ml, with a high positivity rate. The instructions suggest using 0.02ml. I am consulting the pharmacy department for clinical diagnosis. Is there any basis for such a small skin test dosage, and is it difficult to observe due to the small amount?
Answer
The value of cefalosporin skin testing is limited, with a relatively high rate of false positives. If the instructions recommend performing a skin test, it should be done using the cefalosporin that will be used, with a concentration of 300ug/ml. For cefotiam, it should be tested according to its instructions, especially if the patient has a history of allergy to penicillin or cefalosporins.