Question
What is the probability of inheriting Marfan syndrome? If the father is a Marfan syndrome patient but the child has not been diagnosed yet, is there a chance that the disease could be passed down to the child through generations?
Answer
According to your description, Marfan syndrome is a genetic connective tissue disorder that is inherited in an autosomal dominant manner and has the characteristic of generational inheritance. The disease features include long and slender limbs, fingers, and toes that are asymmetrical, significantly taller than average, accompanied by cardiovascular abnormalities, particularly heart valve anomalies and aortic aneurysms. Additionally, it may affect other organs such as the lungs, eyes, dura mater, and jawbone. It is recommended that you take your child to a local hospital for a detailed examination to confirm the diagnosis.