Question

What are the possible causes of high total bilirubin in neonates?

Answer

Liver dysfunction may be the cause of high total bilirubin in neonates, which could result from the damage to liver cells, including cell necrosis and apoptosis. This damage can lead to the release of enzymes from liver cells into the bloodstream and reduce the function of liver cells in synthesizing proteins and glycogen, as well as cause the retention of unprocessed bilirubin and ammonia in the blood. It is recommended to conduct a detailed check of liver function and hepatitis B surface antigen (HBsAg) and antibody (HBeAg) tests.