Question
What is the best treatment plan for a 9-year-old girl with precocious puberty?
Answer
The treatment of this condition depends on the underlying cause. The treatment goals for central precocious puberty include: ① Suppressing or slowing down the rate of development, particularly to prevent the onset of menstruation in girls; ② Inhibiting bone maturation to improve final adult height; ③ Restoring appropriate psychological behavior for the corresponding age. Medroxyprogesterone acetate, also known as Progesterone acetate, is a derivative of progesterone used for girls with precocious puberty. The daily oral dose is 10-30mg, and the dose is reduced after the onset of therapeutic effects. Cyproterone acetate is a derivative of 17α-hydroxyprogesterone and not only blocks sex hormone receptors but also reduces the release of gonadotropins. The dose is 70-150mg/m2 per day. These two drugs do not improve adult height.