Question
What are the effects of allergic purpura on children?
Answer
Allergic purpura, also known as Henoch-Schönlein syndrome, is a systemic vasculitis characterized by primarily small vessel inflammation. It is most common in children aged 2-8, with boys being more affected than girls. Clinical symptoms can vary, with most cases presenting acutely, including skin purpura, gastrointestinal and joint symptoms, as well as renal symptoms. Approximately 30-60% of cases show renal involvement with clinical manifestations, often occurring within one month. Symptoms can range from mild to severe, with most presenting with hematuria, proteinuria, and casts, along with increased blood pressure and edema, known as purpuric nephritis. However, most patients fully recover; only a few may develop into chronic nephritis. Occasionally, intracranial hemorrhage or nosebleeds may occur. The prognosis for this condition is generally good, with the course of the disease usually lasting from 1-2 weeks to 1-2 months, although some cases may be longer. Renal involvement is often protracted, lasting several months or years, with 1% progressing to a persistent renal disease. This is a common case that can be treated in most hospitals.