Question
What are the possible causes of neonatal persistent cholestasis?
Answer
The causes of neonatal persistent cholestasis can be categorized into three main types: liver cell damage, intrahepatic bile duct diseases, and extrahepatic bile duct diseases. Viral hepatitis, such as hepatitis A virus (HAV), has not been found to be transmitted through the placenta to cause intrauterine infection in infants. Cytomegalovirus (CMV) is one of the main causes of neonatal cholestasis in China. In addition, toxoplasmosis, hyperbilirubinemia, and α1-antitrypsin deficiency may also lead to this condition.