Question
How to Interpret the Results of a Down Syndrome Screening?
Answer
The Down syndrome screening is conducted by measuring the concentrations of alpha-fetoprotein, chorionic gonadotropin, and free estriol in maternal serum, and combining this with the woman’s due date, weight, age, and gestational age at the time of blood collection to estimate the risk of fetal congenital defects. During prenatal checkups, all pregnant women undergo this screening to try to identify children with Down syndrome. Individuals with Down syndrome typically suffer from severe intellectual disabilities, which can impose significant emotional and economic burdens on families, making Down syndrome screening very important.