Question
Does the large Y chromosome lead to abnormal embryo development and spontaneous abortion?
Answer
The relationship between the large Y chromosome and spontaneous abortion and abnormal embryo development is still controversial. Although the incidence of the large Y chromosome in the general population is similar to that of the general population, more and more studies suggest that the large Y chromosome may be associated with pregnancy loss and abnormal embryo development. In addition, the large Y chromosome may also be associated with male sexual development abnormalities, hypospadias, and other conditions. In early pregnancy, if there is exposure to teratogenic drugs or infection with TORCH pathogens, the incidence of the large Y chromosome may increase, which may be related to cell DNA mutation. In clinical practice, for families with relevant medical histories, genetic counseling and necessary prenatal diagnosis should be provided.