Question
What is the risk value range for newborn Down syndrome screening?
Answer
The low-risk value for Down syndrome screening is approximately 1 in 270 or below, with the critical risk ranging between 1 in 270 and 1 in 1000. The detection rate for such screenings is about 60% to 70%, with a false-positive rate exceeding 5%. When the screening result indicates critical risk, non-invasive prenatal testing or amniocentesis should be conducted for further confirmation. Non-invasive prenatal testing has a detection rate as high as 99.9%, while amniocentesis can reach a detection rate of 99.9%.