Question

A 28-year-old woman, who has experienced two miscarriages, has been diagnosed with chromosomal balanced translocation, specifically involving the 9th and 11th chromosomes. She asks whether in vitro fertilization is necessary and what the chances of natural conception are, expressing concern about potential fetal deformities. She also inquires about the better domestic in vitro fertilization hospitals and the success rates and costs involved.

Answer

Chromosomal abnormalities may lead to miscarriage, necessitating genetic counseling and taking appropriate measures, such as prenatal diagnostic tests or considering in vitro fertilization. Since at least one of the couple has chromosomal abnormalities, typically only the third-generation in vitro fertilization can be performed to increase the chances of healthy offspring, with higher success rates. At the same time, it is recommended that both partners undergo ultrasound and blood tests as preparatory work to determine the success rate of in vitro fertilization.