Question
What are the impacts of female chromosome abnormalities on fertility and children?
Answer
For females with intercalary translocation of chromosome 6, the effects of this chromosomal abnormality on fertility and offspring mainly include:
- Abnormal pairing of chromosomes during meiosis may lead to an abnormal number of chromosomes in gametes (ova or sperm), thereby affecting pregnancy.
- Even if pregnancy is successful, abnormal chromosomal pairing may increase the risk of chromosomal abnormalities in the embryo, further affecting fetal health.
- In cases of in vitro fertilization (IVF), the translocated chromosomes may increase the proportion of chromosomally abnormal embryos during embryo culture, impacting embryo quality and implantation rate.