Question
The couple has been married for three years without any children. They recently began planning for a family, but a check-up revealed chromosomal abnormalities. They are inquiring whether chromosomal abnormalities can be resolved through IVF techniques.
Answer
Before considering in vitro fertilization (IVF) techniques, it is crucial to first determine the nature and type of the chromosomal abnormalities, which typically involves conducting routine chromosome analysis and related molecular genetic tests. If the chromosomal abnormality is structural, such as a deletion, inversion, or translocation, further tests like FISH (fluorescence in situ hybridization) or other specialized tests may be necessary to precisely locate the abnormality and assess its potential impact on fertility and embryo health. In some cases, options such as ICSI (intracytoplasmic sperm injection) combined with pre-implantation genetic diagnosis (PGD) or pre-implantation genetic screening (PGS) may be considered. These techniques can detect chromosomal abnormalities before embryo transfer, thereby increasing the chances of successful pregnancy and delivering a healthy baby. However, the effectiveness and applicability of these treatments depend on the specific type of chromosomal abnormality and the medical team’s assessment of the individual case. It is recommended to seek advice from a specialist physician or genetic counselor to obtain personalized advice and treatment plans.