Preventing the Occurrence of Down Syndrome

Question

How can the occurrence of Down syndrome be prevented?

Answer

Down syndrome is a disease caused by chromosomal structural abnormalities, with the direct cause being the failure of the 21st chromosome to pair during meiosis in the egg, resulting in an abnormal ovum and leading to a karyotype of 47, XX(XY), +21. Both advanced age (35 years and above) and early age (below 20 years) are risk factors for the recurrence of Down syndrome, and there are also reports linking it to advanced paternal age. Currently, the exact pathogenesis of Down syndrome is not yet clear, and researchers have conducted many experiments in embryology and neuropathology, making significant progress. It is inferred that this malformation may be selected by trisomic genes.

How to Prevent the Occurrence of Down Syndrome?

Answer

Down syndrome is a condition caused by chromosomal structural abnormalities, with the direct cause being the failure of the 21st chromosome to pair during meiosis in the egg, resulting in an abnormal ovum that leads to a karyotype of 47, XX(XY), +21. Both advanced age (over 35) and early age (under 20) are risk factors for the recurrence of Down syndrome, and there are also reports suggesting a link to advanced paternal age. The exact mechanism behind the onset of Down syndrome is still not fully understood. Researchers have conducted extensive studies in embryology and neuropathology, achieving significant advancements. It is believed that this abnormality may be selected by trisomic genes.