Question
The child next door has been frequently showing strange expressions on his face lately, and he has a large head and a small face. My friend is very puzzled. His parents told me that a few days ago, he went to a hospital in the county city for a check-up, and the doctor said he has pediatric clavicle and skull developmental disorder.
Answer
Pediatric clavicle and skull developmental disorder is a congenital skeletal system developmental anomaly, often hereditary developmental disorder. The disease-causing gene has been confirmed as “RUNX2 locus” on chromosome 6, controlling the special transcription factor gene mutation of osteoblasts, affecting the range including slow ossification of the skull, slow closure of sutures, which may gradually ossify until the age of 4 and may not be completed until adulthood. It is necessary to avoid head injuries or compression at all times to protect the head.