Question
A 5-year-old child has undergone a coagulation four tests, and the results show that they are not up to standard. Does this mean there is a problem related to blood? What could be the reasons for an abnormal coagulation four test?
Answer
An abnormal coagulation four test can be associated with various factors. Normally, the nasal mucosa, oral mucosa, and mucous membranes of the gastrointestinal tract do not bleed spontaneously due to the presence of good coagulation factors in the body. These coagulation factors are mainly produced by the liver, which needs to continuously synthesize new coagulation factors to sustain supply since they have a short lifespan and are quickly apoptotic. An abnormal coagulation four test may be related to vascular factors, including both intrinsic vascular abnormalities and extrinsic vascular abnormalities. For example, allergic purpura, scurvy, and hereditary angiokeratoma are caused by intrinsic vascular abnormalities; while senile purpura, hyperhomocystinemia, and others are caused by extrinsic abnormalities. It is recommended to undergo further examination and decide whether treatment is needed based on the doctor’s advice.