Question
When a leukemia patient develops leukoencephalopathy, which treatment option is more suitable for L2 high-risk patients: bone marrow transplantation or continuous chemotherapy?
Answer
Leukoencephalopathy is a brain structural change characterized by involvement of white matter tracts in high-level brain functions. Clinical symptoms include lack of focus, headaches, decreased memory, numbness, amnesia, personality changes, dementia, coma, and even death. The typical response of white matter to various harmful stimuli is demyelination, which may be a secondary manifestation of neurological diseases such as infections, poisoning, degeneration, post-traumatic, and ischemic events.