Is it Lactic Acidemia or Another Genetic Metabolic Disorder?

A child who was unable to roll over and had weak neck muscles since 5 months of age. At 12 months, the child began to make sounds and crawl quickly; at 18 months, they started learning to sit and could stand against the wall but not for long, with poor balance. The child underwent the following examinations at Guangzhou Children’s Hospital: brain CT (normal plain scan), lumbar spine X-ray (normal plain scan), GCMS analysis showed large amounts of succinate, moderate amounts of pyruvate, lactate, and small amounts of fumarate in urine, MR imaging showed bilateral ventriculomegaly, karyotyping did not reveal any abnormalities, blood lactate was elevated (1.8), blood ammonia was normal (22), plasma acylcarnitine analysis showed elevated levels of amino acids such as glutamine, mitochondrial encephalomyopathy gene testing did not find the A3243G (MELAS), A8344G (MERRF), T8993G/C (LS) mutations. Please diagnose and treat.
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Is It More Scary if Hand, Foot, and Mouth Disease Recurs?

My child contracted hand, foot, and mouth disease on October 20th. I discovered sores on their mouth and feet. Last night, on November 13th, I found a few blisters in their mouth and some on their hands. I want to know if recurrence is more horrible (scary) and whether it might be worse than the last time. How should it be treated? I suggest taking the child to the hospital for a routine blood test. The results will show if there are more viral infections and if there are bacterial infections. The medication you provided is effective against both viral and bacterial infections. Also, pay attention to diet and personal hygiene. At the same time, the child should wash their hands frequently and consistently take the medication for a week. Then, recheck the routine blood test indicators. If all indicators are normal, that’s fine. Western medicine for hand, foot, and mouth disease mainly involves antiviral treatment and symptomatic treatment, while traditional Chinese medicine is also a good option.
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Is It Necessary for a Baby with Jaundice Level 13 on the 5th Day of Life to Be Admitted to the Hospital?

There are many causes of jaundice, and it is necessary to judge whether it is physiological jaundice or pathological jaundice based on the baby’s mode of birth and the time jaundice appears. Physiological jaundice usually appears 2-3 days after birth and gradually disappears in 7-10 days, so hospitalization is not necessary. Pathological jaundice may require hospitalization for further examination and treatment.
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